RJ vs. TP in AirlineSim

I think you are underestimate cruise consumption difference heavily. Quick search gave me figures of ~1300kg/hour of cruise flight for CR2

and ~600kg/hour for ATR42, which is more, than 100% difference. Cruise speed, on the other hand, differs between them only around 40%.

So to get better on fuel consumption you need to cruise RJ for at least 2-3 hours, which give you "target" route length above 2000km.

If you check ATR42 vs CR2 in AS on a route over 2kkm you’ll get the results you are expecting.