I have a lot of experience with AS but never really made a cargo airline work. I now tried a bit on Kaitak. Apart from that world being really saturated with long lasting airline companies settled I recently noticed I do have full flights. But the revenue is devastating.
So what I see is: I fly a 737-700C from IND to MEM. I have an own cargo terminal working. Nevertheless to reach the break even in earnings I would need to have a plus 50 percent price calculation. I probably could lower this rate in using an owned plane. Still this shows that making money with a cargo airline I need full flights with the lowest possible expenditure and around 40 to 50 percent above price calculations. This seems impossible to me.
Second question: is a hub and spoke system with cargo as effective as it is with pax? Seems to me cargo flights are less responding to connections.
Hard to advice you anything on Kaitak as it is so saturated.
But in general: IND-MEM is too short to make money. However, these flights can be feeder flights (no, they are feeder flights) and yes, connections are also key in flying cargo.
Find a unsaturated area and find your way there.
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Thank you so much, highscor 
I calculated the same pricage on longer routes like IND-HKG or IND-CGN. Even those will need a 35-50 percent prica addition.
20 - 25 is enough. But yes, you need more money than standard price. Same as for passengers.
I don’t know the situation today on Kaitak but if you have competition in cargo, you need to find other spots than IND. South America for example.
Hm. Competition is not my problem. I do fill my planes. But to be profitable, as said, I need an owned plane, 35 % plus prices and an own terminal. I noticed this with routes like CGN-HKG, IND-MEM, IND-HKG, BAH-MAA, BAH-ICN. And I used different types of aircraft: 73G, 76Y, 33F.
Can you share a financial document of some of your flights?
I never need these high prices as mentioned and still have a huge margin.
Well, from my experience on Limatambo and a 2 year old cargo airline, I can tell you even without purchased planes or owning an terminal you can make profits. I do not have a 737 on this route but for example an TU 204-100C would generate a profit margin of 38% and an ATR 72-500F 27%.
Connection looks important too, SDF as my main hub has a internal transfer of 70% with around 6159 departures. but I do have other airports where I just schedule as long as the planes are 100% without any look on schedule or waves, I only have 3324 departures but for example only an internal transfer of 8%